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Skeletal effects and growth in children with chronic kidney disease: a 5-year prospective study
University of Gothenburg, Sweden .
University of Gothenburg, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Chemistry.
2013 (English)In: Journal of Bone and Mineral Metabolism, ISSN 0914-8779, E-ISSN 1435-5604, Vol. 31, no 3, 322-328 p.Article in journal (Refereed) Published
Abstract [en]

This study was designed to follow the evolving process of growth, bone modeling and remodeling in children with chronic kidney disease (CKD) who are at risk of developing CKD-mineral bone disorder (CKD-MBD). Fifteen patients, 4-15 years, were included with a median glomerular filtration rate of 46 (range 12-74) mL/min/1.73 m(2). Growth, bone mineral density (BMD) and markers of bone and mineral metabolism were investigated over a 5-year period. The median height standard deviation score was -0.65 at the start and 0.1 after 5 years, with a range from -1.7 to 1.7, which implies that growth was acceptable. Total body, femoral neck, and lumbar spine BMD increased over the study period (p andlt; 0.0001). None had total body BMD Z-scores and lumbar spine Z-scores below -2.0 at follow-up. Most bone markers were within the reference intervals, but the formation markers of alkaline phosphatase and type I procollagen intact amino-terminal propeptide (PINP) were slightly increased in about one-third of the patients after 5 years. Eleven out of 15 CKD patients had increased parathyroid hormone levels at baseline and 10 patients after 5 years had increased parathyroid hormone levels. Taken together, this is the first 5-year longitudinal study of skeletal effects, growth and bone turnover in children with CKD. Growth and BMD Z-scores were well preserved on a group basis; however, these parameters varied significantly on an individual basis. We suggest, therefore, that it is difficult to state an overall recommendation and growth, bone mass, and markers of bone and mineral metabolism should be monitored and treated individually in CKD children.

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 31, no 3, 322-328 p.
Keyword [en]
Bone metabolism markers, Bone mineral density, Dual-energy X-ray absorptiometry, Growth, Renal osteodystrophy
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-94610DOI: 10.1007/s00774-012-0412-yISI: 000319295000009OAI: diva2:633576

Funding Agencies|Swedish Research Council||Swedish Society of Medicine||Swedish Association for Kidney Patients||County Council of Ostergotland||Goteborg Medical Society||

Available from: 2013-06-27 Created: 2013-06-27 Last updated: 2013-06-27

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Magnusson, Per
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Clinical ChemistryFaculty of Health SciencesDepartment of Clinical Chemistry
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