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The effect of aging on cochlear amplifier: A simulation approach using a physiologically-based electro-mechanical model of the cochlea
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-3350-8997
2012 (English)In: Canadian Acoustics, ISSN 0711-6659, Vol. 40, no 3, 128-129 p.Article in journal (Refereed) Published
Abstract [en]

The electrical, acoustical, and mechanical elements of the cochlea are explicitly integrated into a transmission-line model to develop a physiological interpretation of the human cochlea insofar. The model enables fundamental simulation of specific cochlear lesions such as metabolic presbyacusis. A sound pressure field in the air is transmitted via the outer and middle ear to the inner ear. It causes the stapes to vibrate resulting in a traveling wave along the organ of Corti propagating from base towards apex. As the endocochlear potential (EP) decreases, the MET produces less receptor current which, eventually leading to a decline in the force/displacement generated by the somatic motor. The CFs of the curves tend to move backwards in a presbyacusis cochlea, this result is consistent with Robles and Ruggem where in a passive cochlea, the CFs are shifted backwards.

Place, publisher, year, edition, pages
Canadian Acoustical Association , 2012. Vol. 40, no 3, 128-129 p.
Keyword [en]
Acoustics; Audio frequency amplifiers; Computer simulation; Physiology; Cochlear amplifiers; Electromechanical models; Endocochlear potentials; Human cochleas; Inner ear; Mechanical elements; Middle ears; Organ of corti; Simulation approach; Sound pressure field; Transmission line models; Traveling wave
National Category
URN: urn:nbn:se:liu:diva-94738OAI: diva2:634745
Available from: 2013-07-01 Created: 2013-07-01 Last updated: 2014-10-08Bibliographically approved
In thesis
1. Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
Open this publication in new window or tab >>Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A hearing impairment is primarily diagnosed by measuring the hearing thresholds at a range of auditory frequencies (air-conduction audiometry). Although this clinical procedure is simple, affordable, reliable and fast, it does not offer differential information about origins of the hearing impairment. The main goal of this thesis is to quantitatively link specific cochlear pathologies to certain changes in the spectral and temporal characteristics of the auditory system. This can help better understand the underlying mechanisms associated with sensorineural hearing impairments, beyond what is shown in the audiogram. Here, an electromechanical signal-transmission model is devised in MATLAB where the parameters of the model convey biological interpretations of mammalian cochlear structures. The model is exploited to simulate the cell-level cochlear pathologies associated with two common types of sensorineural hearing impairments, 1: presbyacusis (age-related hearing impairment) and, 2: noise-induced hearing impairment. Furthermore, a clinical study, consisting of different psychoacoustic and physiological tests, was performed to trace and validate the model predictions in human. The results of the clinical tests were collated and compared with the model predictions, showing a reasonable agreement. In summary, the present model provides a biophysical foundation for simulating the effect of specific cellular lesions, due to different inner-ear diseases and external insults, on the entire cochlear mechanism and thereby on the whole auditory system. This is a multidisciplinary work in the sense that it connects the ‘biological processes’ with ‘acoustic modelling’ and ‘clinical audiology’ in a translational context.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 57 p.
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1400Studies from the Swedish Institute for Disability Research, ISSN 1650-1128 ; 60
Auditory modeling, cochlear mechanics, sensorineural hearing impairment, age-related hearing loss, noise-induced hearing loss, inner ear pathologies
National Category
Medical and Health Sciences
urn:nbn:se:liu:diva-105810 (URN)10.3384/diss.diva-105810 (DOI)978-91-7519-365-6 (print) (ISBN)
Public defence
2014-04-28, Nils Holger salen, entrance 71, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2014-10-08Bibliographically approved

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Stenfelt, Stefan
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Technical AudiologyFaculty of Health Sciences
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