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A skewed thiopurine metabolism is a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-2809-7591
Blekinge Hospital, Sweden .
Skåne University Hospital, Sweden .
2013 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 7, no 6, 510-513 p.Article in journal (Refereed) Published
Abstract [en]

Background and aims: A skewed thiopurine metabolism is a phenomenon associated with both poor treatment response and toxicity. Our aim was to evaluate the frequency of this phenomenon and the relationship to thiopurine methyltransferase (TPMT) function. less thanbrgreater than less thanbrgreater thanMethods: All thiopurine metabolite measurements in adult patients (n=4033) between January 2006 and April 2012 were assessed to evaluate the occurrence of a skewed metabolism and the relationship to TPMT genotype and activity. less thanbrgreater than less thanbrgreater thanResults: A skewed metabolism was observed in 14% of all patients. It only developed in patients with a normal TPMT genotype, but was observed at all TPMT activity levels within the normal range (9.1-24.2 U/ml RBC). Two cases that illustrate typical clinical scenarios of a skewed metabolism and the effect of combination treatment with low-dose azathioprine and allopurinol are presented. less thanbrgreater than less thanbrgreater thanConclusions: A skewed metabolism is a common clinical phenomenon in patients with a normal TPMT function, which can develop at all TPMT activity levels within the normal range. We suggest that metabolite measurements should be considered in patients not responding to treatment and in those with hepatotoxicity or myelotoxicity in order to detect a skewed metabolism, since this phenomenon can be successfully managed by a combination of low-dose azathioprine and allopurinol.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 7, no 6, 510-513 p.
Keyword [en]
Thiopurine methyltransferase, Thiopurines, Inflammatory bowel diseases
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-95496DOI: 10.1016/j.crohns.2012.10.016ISI: 000319370300010OAI: oai:DiVA.org:liu-95496DiVA: diva2:635790
Available from: 2013-07-05 Created: 2013-07-05 Last updated: 2017-12-06

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Lindqvist Appell, Malin

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