No association of primary Sjogrens syndrome with Fc gamma receptor gene variants
2013 (English)In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 14, no 4, 234-237 p.Article in journal (Refereed) Published
The genetic background of primary Sjogrens syndrome (pSS) is partly shared with systemic lupus erythematosus (SLE). Immunoglobulin G Fc receptors are important for clearance of immune complexes. Fcg receptor variants and gene deletion have been found to confer SLE risk. In this study, four Fc gamma receptor single-nucleotide polymorphisms (SNPs) and one copy number variation (CNV) were studied. Swedish and Norwegian pSS patients (N = 527) and controls (N = 528) were genotyped for the Fc gamma receptor gene variant FCGR2A H131R (rs1801274) by the Illumina GoldenGate assay. FCGR3A F158V (rs396991) was analysed in 488 patients and 485 controls, FCGR3B rs447536 was analysed in 471 patients and 467 controls, and FCGR3B rs448740 was analysed in 478 cases and 455 controls, using TaqMan SNP genotyping assays. FCGR3B CNV was analysed in 124 patients and 139 controls using a TaqMan copy number assay. None of the SNPs showed any association with pSS. Also, no FCGR3B CNV association was detected. The lack of association of pSS with Fc gamma receptor gene variants indicates that defective immune complex clearance may not be as important in pSS pathogenesis as in SLE, and may point to important differences between SLE and pSS.
Place, publisher, year, edition, pages
Nature Publishing Group: Open Access Hybrid Model Option B , 2013. Vol. 14, no 4, 234-237 p.
Sjogrens syndrome; Fc gamma receptors; single-nucleotide polymorphism; DNA copy number variations
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-96121DOI: 10.1038/gene.2013.12ISI: 000320029300005OAI: oai:DiVA.org:liu-96121DiVA: diva2:640769