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Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Paediatrics in Linköping.
University of Lund Hospital, Sweden .
Lund University, Sweden .
Queen Silvia Childrens Hospital, Sweden .
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2013 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 100, no 2, 203-209 p.Article in journal (Refereed) Published
Abstract [en]

Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. less thanbrgreater than less thanbrgreater thanMethods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. less thanbrgreater than less thanbrgreater thanResults: Younger children lost more C-peptide (p andlt; 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p andlt; 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p andlt; 0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p andlt; 0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p andlt; 0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. less thanbrgreater than less thanbrgreater thanConclusions/interpretation: Even in a restricted geographical area and narrow age range (andlt; 18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 100, no 2, 203-209 p.
Keyword [en]
C-peptide, Natural course, Type 1 diabetes, Children, BMI, Intervention trials
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-95977DOI: 10.1016/j.diabres.2013.03.003ISI: 000320590900016OAI: oai:DiVA.org:liu-95977DiVA: diva2:641631
Note

Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden)||National Institutes of Health|DK63861DK26190|Swedish Research Council||EU|202013|

Available from: 2013-08-19 Created: 2013-08-12 Last updated: 2017-12-06

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Ludvigsson, JohnnySamuelsson, Ulf

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Division of Clinical SciencesFaculty of Health SciencesDepartment of Paediatrics in Linköping
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