Decline of C-peptide during the first year after diagnosis of Type 1 diabetes in children and adolescents
2013 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 100, no 2, 203-209 p.Article in journal (Refereed) Published
Aims/hypothesis: We studied the decline of C-peptide during the first year after diagnosis of Type 1 diabetes (T1D), and its relation to various factors. less thanbrgreater than less thanbrgreater thanMethods: 3824/4017 newly diagnosed patients (95%) were classified as T1D in a national study. In a non-selected subgroup of 1669 T1D patients we determined non-fasting C-peptide both at diagnosis and after 1 year, and analyzed decline in relation to clinical symptoms and signs, initial C-peptide and occurrence of auto-antibodies. less thanbrgreater than less thanbrgreater thanResults: Younger children lost more C-peptide (p andlt; 0.001) and the higher the C-peptide at diagnosis the larger the decline during the first year (p andlt; 0.0000). Patients with higher BMI had higher C-peptide at diagnosis but lost more (p andlt; 0.01), and those with lower HbA1c, without symptoms and signs at diagnosis, and with higher BMI, had higher C-peptide at diagnosis, but lost more during the first year (p andlt; 0.001). Finally, patients diagnosed during autumn had higher C-peptide at diagnosis, but lost more during the coming year (p andlt; 0.001). Occurrence of auto-antibodies did not correlate with C-peptide decline, except possibly for a more rapid loss in IAA-positive patients. less thanbrgreater than less thanbrgreater thanConclusions/interpretation: Even in a restricted geographical area and narrow age range (andlt; 18 years), the natural course of Type 1 diabetes is heterogeneous. This should be considered in clinical trials.
Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 100, no 2, 203-209 p.
C-peptide, Natural course, Type 1 diabetes, Children, BMI, Intervention trials
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-95977DOI: 10.1016/j.diabres.2013.03.003ISI: 000320590900016OAI: oai:DiVA.org:liu-95977DiVA: diva2:641631
Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden)||National Institutes of Health|DK63861DK26190|Swedish Research Council||EU|202013|2013-08-192013-08-122013-08-19