Family psychological stress early in life and development of type 1 diabetes: The ABIS prospective study
2013 (English)In: Diabetes Research and Clinical Practice, ISSN 0168-8227, E-ISSN 1872-8227, Vol. 100, no 2, 257-264 p.Article in journal (Refereed) Published
Aims: This study investigated whether psychological stress in the family during the childs first year of life are associated with the risk of childhood type 1 diabetes (T1D). According to the beta-cell stress hypothesis all factors that increase the need for, or the resistance to, insulin may be regarded as risk factors for T1D. less thanbrgreater than less thanbrgreater thanMethods: Among 8921 children from the general population with questionnaire data from one parent at childs birth and at 1 year of age, 42 cases of T1D were identified up to 11-13 years of age. Additionally 15 cases with multiple diabetes-related autoantibodies were detected in a sub-sample of 2649 children. less thanbrgreater than less thanbrgreater thanResults: Cox regression analyses showed no significant associations between serious life events (hazard ratio 0.7 for yes vs. no [95% CI 0.2-1.9], p = 0.47), parenting stress (0.9 per scale score [0.5-1.7], p = 0.79), or parental dissatisfaction (0.6 per scale score [0.3-1.2], p = 0.13) during the first year of life and later diagnosis of T1D, after controlling for socioeconomic, demographic, and diabetes-related factors. Inclusion of children with multiple autoantibodies did not alter the results. less thanbrgreater than less thanbrgreater thanConclusions: No association between psychological stress early in life and development of T1D could be confirmed.
Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 100, no 2, 257-264 p.
Diabetes mellitus, Type 1, Stress, Psychological, Life change events, Educational status, Prospective studies
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-95975DOI: 10.1016/j.diabres.2013.03.016ISI: 000320590900024OAI: oai:DiVA.org:liu-95975DiVA: diva2:641636
Funding Agencies|Swedish Research Council|K2005-72X-11242-11AK2008-69X-20826-01-4|Swedish Child Diabetes Foundation (Barndiabetesfonden)||JDRF Wallenberg Foundation|K 98-99D-12813-01A|Medical Research Council of Southeast Sweden (FORSS)||Swedish Council for Working Life and Social Research|FAS2004-1775|2013-08-192013-08-122015-09-04Bibliographically approved