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Health-Related Quality of Life of Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes-Results from the PLATO Trial
Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Health Sciences.
Uppsala University, Sweden .
Linköping University, Department of Medical and Health Sciences, Division of Health Care Analysis. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences. Linköping University, Faculty of Health Sciences.
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2013 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 16, no 4, 574-580 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The purpose of this study was to compare the effects of ticagrelor versus clopidogrel on health-related quality of life in the PLATelet inhibition and patient Outcomes (PLATO) trial. Background: The PLATO trial showed that ticagrelor was superior to clopidogrel for the prevention of cardiovascular death, myocardial infarction, or stroke in a broad population of patients with acute coronary syndromes. Methods: HRQOL in the PLATO study was measured at hospital discharge, 6-month visit, and end of treatment (anticipated at 12 months) by using the EuroQol five-dimensional (EQ-5D) questionnaire. All patients who had an EQ-5D questionnaire assessment at discharge from the index hospitalization (n = 15,212) were included in the study. Patients who died prior to the end-of-treatment visit were assigned an EQ-5D questionnaire value of 0. Results: The EQ-5D questionnaire value at discharge among 7631 patients assigned to ticagrelor was 0.847 and among 7581 patients assigned to clopidogrel was 0.846 (P = 0.71). At 12 months, the mean EQ-5D questionnaire value was 0.840 for ticagrelor and 0.832 for clopidogrel (P = 0.046). Excluding patients who died resulted in mean EQ-5D questionnaire values of 0.864 among ticagrelor patients and 0.863 among clopidogrel patients (P = 0.69). Conclusions: In patients hospitalized with acute coronary syndromes with or without ST-segment elevation, treatment with ticagrelor was associated with a lower mortality but otherwise no difference in quality of life relative to treatment with clopidogrel. The improved survival and reduction in cardiovascular events with ticagrelor are therefore obtained with no loss in quality of life.

Place, publisher, year, edition, pages
Wiley-Blackwell: No OnlineOpen / Elsevier , 2013. Vol. 16, no 4, 574-580 p.
Keyword [en]
acute coronary syndrome, clopidogrel, quality of life, ticagrelor
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-95968DOI: 10.1016/j.jval.2013.01.013ISI: 000321440900016OAI: oai:DiVA.org:liu-95968DiVA: diva2:641645
Note

Funding Agencies|AstraZeneca||

Available from: 2013-08-19 Created: 2013-08-12 Last updated: 2017-12-06

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Levin, Lars-ÅkeBernfort, LarsJanzon, Magnus

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Levin, Lars-ÅkeBernfort, LarsJanzon, Magnus
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Division of Health Care AnalysisFaculty of Health SciencesDepartment of Medical and Health SciencesCardiologyDepartment of Cardiology in Linköping
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