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Genetic evidence for involvement of adaptive immunity in the development of IgA nephropathy: MHC class II alleles are protective in a Caucasian population
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Sahlgrens University Hospital, Sweden .
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2013 (English)In: Human Immunology, ISSN 0198-8859, E-ISSN 1879-1166, Vol. 74, no 8, 957-960 p.Article in journal (Refereed) Published
Abstract [en]

There is evidence suggesting that IgA nephropathy (IgAN) is an immunological disease. The role of FILA class II DR beta 1 (DRB1) has previously not been well studied. The aim of our study was to investigate the association of HLA-DRB1 variants with IgAN in a Swedish Caucasian cohort. Our study consisted of 213 patients with biopsy proven IgAN, all of self-reported Caucasian ancestry. As a control cohort, 1569 healthy subjects from the same population in Sweden were included. HLA-DRB1 low-resolution genotyping was performed and odds ratios were calculated to assess the risk. less thanbrgreater than less thanbrgreater thanIn an allelic model the HLA-DRB1*03 and *10, demonstrated association for IgAN after correction for multiple comparison, with subsequent OR = 0.54 (95% CI 0.37-0.78) and 3.44 (95% Cl 1.67-7.07). When the influence of risk allelic groups was adjusted for protective allelic groups and vice versa, only a protective effect of HLA-DRB1*03 remained significant. less thanbrgreater than less thanbrgreater thanIn conclusion, the variants of HLA-DRB1 were associated with IgAN of which the HLA-DRB1*03 revealed a strong protective effect for IgAN. Our data replicates finding from other Caucasian populations and suggest that involvement of adaptive immunity may be of importance in the development of the disease.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 74, no 8, 957-960 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-95939DOI: 10.1016/j.humimm.2013.04.016ISI: 000321795600010OAI: diva2:641767

Funding Agencies|SIDAs Secretariat for Research Cooperation|750073030375007342|Swedish Research Council||

Available from: 2013-08-19 Created: 2013-08-12 Last updated: 2013-08-19

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Fernström, Anders
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NephrologyFaculty of Health SciencesDepartment of Nephrology
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