Thyroid autoimmunity in relation to islet autoantibodies and HLA-DQ genotype in newly diagnosed type 1 diabetes in children and adolescents
2013 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 56, no 8, 1735-1742 p.Article in journal (Refereed) Published
The aim of this work was to investigate, in children newly diagnosed with type 1 diabetes: (1) the prevalence of autoantibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb); and (2) the association between TPOAb, TGAb or both, with either islet autoantibodies or HLA-DQ genes. less thanbrgreater than less thanbrgreater thanBlood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc transporter 8 (ZnT8WA), glutamine zinc transporter 8 (ZnT8QA), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), HLA-DQA-B1 genotypes, thyroid-stimulating hormone (TSH) and free thyroxine (T4). less thanbrgreater than less thanbrgreater thanAt type 1 diabetes diagnosis, 12% of the children had thyroid autoantibodies (60% were girls; p andlt; 0.0001). GADA was positively associated with TPOAb (p andlt; 0.001) and with TGAb (p andlt; 0.001). In addition, ZnT8A was associated with both TPOAb (p = 0.039) and TGAb (p = 0.015). DQB1*05:01 in any genotype was negatively associated with TPOAb (OR 0.55, 95% CI 0.37, 0.83, p value corrected for multiple comparisons (p (c)) = 0.012) and possibly with TGAb (OR 0.55, 95% CI 0.35, 0.87, p (c) = 0.07). Thyroid autoimmunity in children newly diagnosed with type 1 diabetes was rarely (0.45%) associated with onset of clinical thyroid disease based on TSH and free T4. less thanbrgreater than less thanbrgreater thanGADA and ZnT8A increased the risk for thyroid autoimmunity at the time of clinical diagnosis of type 1 diabetes, while HLA-DQB1*05:01 reduced the risk. However, the associations between thyroid autoimmunity and HLA-DQ genotype were weak and did not fully explain the co-occurrence of islet and thyroid autoimmunity.
Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 56, no 8, 1735-1742 p.
Autoimmune thyroid diseases, Diabetes mellitus, GAD65 autoantibodies, HLA genotype, IA-2 autoantibodies, Insulin autoantibodies, Thyroglobulin antibodies, Thyroid peroxidase antibodies, Type 1 diabetes, ZnT8 autoantibodies
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-95936DOI: 10.1007/s00125-013-2934-9ISI: 000321285400009OAI: oai:DiVA.org:liu-95936DiVA: diva2:641773
Funding Agencies|Swedish Research Council|14064|Swedish Child Diabetes Foundation||Swedish Diabetes Association||National Institutes of Health|DK26190|SUS Fund||Knut and Alice Wallenberg Foundation||Skane County Council for Research and Development||2013-08-192013-08-122013-08-19