liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer
Sichuan University, China.
Sichuan University, China.
Sichuan University, China.
Sichuan University, China.
Show others and affiliations
2013 (English)In: Tumor Biology, ISSN 1010-4283, E-ISSN 1423-0380, Vol. 34, no 4, 2175-2181 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies from our laboratory identified a number of miRNAs that were aberrantly expressed in colorectal cancer (CRC) tissue. However, their diagnostic and prognostic value in serum has not been fully evaluated. In the present study, we measured the levels of five miRNAs (miR-21, miR-31, miR-92a, miR-18a, and miR-106a) in serum samples from 200 CRC patients, 50 advanced adenoma patients, and 80 healthy controls by real-time quantitative polymerase chain reaction (RT-PCR). In our study, the levels of miR-21 and miR-92a in patients with CRC and advanced adenoma were significantly higher than those in healthy controls (all P  < 0.05). MiR-21 yielded an area under the receiver-operating characteristics (ROC) curve (AUC) of 0.802 and miR-92a yielded an AUC of 0.786 in discriminating CRCs from the controls. Additionally, miR-21 and miR-92a yielded an AUC of 0.709 and 0.701, respectively, in discriminating advanced adenomas from the controls. Combined ROC analyses using both miRNAs, revealed an elevated AUC of 0.847 in discriminating CRCs, and an AUC of 0.722 in discriminating advanced adenomas from the controls. In the multivariate Cox proportional hazards analysis, high miR-92a expression in CRC was independently associated with poor survival (P = 0.03; hazard ratio 4.36; 95 % confidence interval = 1.64–11.57). No significant difference was observed in the levels of miR-18a, miR-31, and miR-106a among CRC, advanced adenoma, and control samples. In summary, our data indicate that miR-21 and miR-92a serum levels have potential value for early detection of CRC. Furthermore, miR-92a has prognostic value in CRC patients.

Place, publisher, year, edition, pages
Karger / Springer Verlag (Germany) , 2013. Vol. 34, no 4, 2175-2181 p.
Keyword [en]
Colorectal cancer, MicroRNA, Serum, Diagnosis, Prognosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-96414DOI: 10.1007/s13277-013-0753-8ISI: 000321912500023OAI: oai:DiVA.org:liu-96414DiVA: diva2:641961
Note

Funding Agencies|National Natural Science Foundation of China|30830103|

Available from: 2013-08-20 Created: 2013-08-19 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(401 kB)628 downloads
File information
File name FULLTEXT01.pdfFile size 401 kBChecksum SHA-512
eab79f8a11bc511687b2fe29336e84ba006d8fc303df1f64affd3865dc8e48fb3e7481e08735ab5143de5b745ec1af7fd99f525413fc7ff6abe3e4c3fb1d29ea
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Sun, Xiao-Feng

Search in DiVA

By author/editor
Sun, Xiao-Feng
By organisation
Division of Clinical SciencesFaculty of Health SciencesDepartment of Oncology
In the same journal
Tumor Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 628 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 126 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf