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Application of sub-regional analysis to bone mineral density of the lower limb from whole body DXA scans
Robert Jones and Agnes Hunt Orthopaed Hospital NHS Fdn, England .
Robert Jones and Agnes Hunt Orthopaed Hospital NHS Fdn, England .
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Robert Jones and Agnes Hunt Orthopaed Hospital NHS Fdn, England .
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Robert Jones and Agnes Hunt Orthopaed Hosp NHS Fdn, England Linkoping Univ, Dept Clin and Expt Med, Div Clin Chem, Linkoping, Sweden .
2013 (English)In: Physiological Measurement, ISSN 0967-3334, E-ISSN 1361-6579, Vol. 34, no 7, 757-768 p.Article in journal (Refereed) Published
Abstract [en]

Bone mineral density at spine and hip is widely used to diagnose osteoporosis. Certain conditions cause changes in bone density at other sites, particularly in the lower limb, with fractures occurring in non-classical locations. Bone density changes at these sites would be of interest for diagnosis and treatment. We describe an application, based on an existing software option for Hologic scanners, which allows reproducible measurement of bone density at six lower limb sites (upper femur, mid-femur, lower femur; upper leg, mid-leg, lower leg). In 30 unselected subjects, referred for bone density, precision (CV%) measured on 2 occasions, separated by repositioning, ranged from 1.7% (mid-femur) to 4.5% at the lowest leg site. Intra-operator precision, measured by three operators on ten subjects on three occasions, was between 1.0% and 2.9%, whilst inter-operator precision was between 1.0% and 3.6%, according to region. These values compare well with those at the spine and upper femur, and in the literature. There was no evidence that this operator agreement improved between occasions 1 and 3. This technique promises to be useful for assessing bone changes at vulnerable sites in the lower limb, in diverse pathological states and in assessing response to treatment.

Place, publisher, year, edition, pages
Institute of Physics: Hybrid Open Access , 2013. Vol. 34, no 7, 757-768 p.
Keyword [en]
DXA regional analysis; lower limb; osteoporosis; whole body DXA
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-96456DOI: 10.1088/0967-3334/34/7/757ISI: 000320815000002OAI: oai:DiVA.org:liu-96456DiVA: diva2:642940
Available from: 2013-08-23 Created: 2013-08-20 Last updated: 2017-12-06

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