Laser speckle contrast imaging: theoretical and practical limitations
2013 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, Vol. 18, no 6Article in journal (Refereed) Published
When laser light illuminates a diffuse object, it produces a random interference effect known as a speckle pattern. If there is movement in the object, the speckles fluctuate in intensity. These fluctuations can provide information about the movement. A simple way of accessing this information is to image the speckle pattern with an exposure time longer than the shortest speckle fluctuation time scale-the fluctuations cause a blurring of the speckle, leading to a reduction in the local speckle contrast. Thus, velocity distributions are coded as speckle contrast variations. The same information can be obtained by using the Doppler effect, but producing a two-dimensional Doppler map requires either scanning of the laser beam or imaging with a high-speed camera: laser speckle contrast imaging (LSCI) avoids the need to scan and can be performed with a normal CCD- or CMOS-camera. LSCI is used primarily to map flow systems, especially blood flow. The development of LSCI is reviewed and its limitations and problems are investigated. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers (SPIE) , 2013. Vol. 18, no 6
laser speckle, laser Doppler, time-varying speckle, medical imaging, blood flow, perfusion
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-96996DOI: 10.1117/1.JBO.18.6.066018ISI: 000322341100058OAI: oai:DiVA.org:liu-96996DiVA: diva2:644847