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A new synthesis of nanoparticles designed for Biomedical Imaging. A pilot study.
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This thesis presents a new procedure for synthesizing nanoparticles with fluorescent and MRI contrast enhancement properties. The produced nanoparticles consist of mixtures between two well-known materials; zinc oxide and gadolinium oxide. Zinc oxide is a well-known semiconductor with visible fluorescence and gadolinium oxide is a paramagnetic material exhibiting excellent magnetic properties for enhancing contrast in MRI. 

The presented synthesis is based on a recently published protocol by Zhang et al [1], for synthesis of pure zinc oxide nanoparticles. The procedure includes a precursor synthesis where respectively metal is dissolved in a solution of water and methacrylic acid. Thereafter the precursors are mixed and dissolved in TEG for a combined nucleation and in-situ polymerization step.

The work in this thesis is multidisciplinary involving molecular design, chemical synthesis, nanoparticle preparation, purification, characterization and also biological applications. The first rounds of nanoparticles were readily dispersible in water, had adequate fluorescent properties, were in a size range suited for in vivo applications and had better relaxivity properties compared to commonly used contrast agent. These results motivate future work including further optimizations of the protocol. This new nanomaterial has high potential as contrast agent for biomedical imaging.

Place, publisher, year, edition, pages
2013. , 69 p.
Keyword [en]
Magnetic Resonance Imaging, Fluorescence, Nanoparticle, Zinc Oxide and Gadolinium Oxide
National Category
Nano Technology
Identifiers
URN: urn:nbn:se:liu:diva-96971ISRN: LITH-IFM-A-EX--13/2832--SEOAI: oai:DiVA.org:liu-96971DiVA: diva2:645371
Subject / course
Physics
Presentation
Röntgen, Linköping (Swedish)
Supervisors
Examiners
Available from: 2013-09-09 Created: 2013-09-02 Last updated: 2013-09-09Bibliographically approved

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Final Thesis(4776 kB)331 downloads
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Department of Physics, Chemistry and BiologyThe Institute of Technology
Nano Technology

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
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  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
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