liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway
Haukeland Hospital, Norway .
University of Bergen, Norway .
University of Bergen, Norway .
University of Bergen, Norway .
Show others and affiliations
2013 (English)In: Langenbeck's archives of surgery (Print), ISSN 1435-2443, E-ISSN 1435-2451, Vol. 398, no 6, 869-874 p.Article in journal (Refereed) Published
Abstract [en]

Primary aldosteronism (PA) is a frequent cause (about 10 %) of hypertension. Some cases of PA were recently found to be caused by mutations in the potassium channel KCNJ5. Our objective was to determine the mutation status of KCNJ5 and seven additional candidate genes for tumorigenesis: YY1, FZD4, ARHGAP9, ZFP37, KDM5C, LRP1B, and PDE9A and, furthermore, the surgical outcome of PA patients who underwent surgery in Western Norway. less thanbrgreater than less thanbrgreater thanTwenty-eight consecutive patients with aldosterone-producing adrenal tumors (20 patients with single adenoma, 8 patients with unilateral multiple adenomas or hyperplasia) who underwent surgery were included in this study. All patients were operated on by uncomplicated laparoscopic total adrenalectomy. Genomic DNA was isolated from tumor and non-tumor adrenocortical tissue, and DNA sequencing revealed the mutation status. less thanbrgreater than less thanbrgreater thanTen out of 28 (36 %) patients with PA displayed tumor mutations in KCNJ5 (p. G151R and L168R) while none were found in the corresponding non-tumor samples. No mutations were found in the other seven candidate genes screened. The presence of KCNJ5 mutations was associated with lower blood pressure and a higher chance for cure by surgery when compared to patients harboring the KCNJ5 wild type. less thanbrgreater than less thanbrgreater thanKCNJ5 mutations are associated with a better surgical outcome. Preoperative identification of the mutation status might have impact on surgical strategy (total vs. subtotal adrenalectomy).

Place, publisher, year, edition, pages
Springer Verlag (Germany) , 2013. Vol. 398, no 6, 869-874 p.
Keyword [en]
Primary aldosteronism, Aldosterone-producing tumors, Conns syndrome, KCNJ5, Somatic mutations, Western Norway
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-96978DOI: 10.1007/s00423-013-1093-2ISI: 000322372500010OAI: diva2:645705

Funding Agencies|Western Norway Regional Health Authority||

Available from: 2013-09-05 Created: 2013-09-02 Last updated: 2014-03-25

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Gimm, Oliver
By organisation
Division of Clinical SciencesFaculty of Health SciencesDepartment of Surgery in Linköping
In the same journal
Langenbeck's archives of surgery (Print)
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 87 hits
ReferencesLink to record
Permanent link

Direct link