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ABCB1 gene polymorphisms are associated with suicide in forensic autopsies
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Clinical Pharmacology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences.
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2013 (English)In: Pharmacogenetics & Genomics, ISSN 1744-6872, E-ISSN 1744-6880, Vol. 23, no 9, 463-469 p.Article in journal (Refereed) Published
Abstract [en]

Background Polymorphisms in ABCB1 have the ability to affect both the function and the expression of the transporter protein P-glycoprotein and may lead to an altered response for many drugs including some antidepressants and antipsychotics.Objective The aim of this study was to examine the impact of the ABCB1 polymorphisms 1199Gandgt;A, 1236Candgt;T, 2677Gandgt;T/A, and 3435Candgt;T in deaths by suicide.Patients and methods A total of 998 consecutive Swedish forensic autopsies performed in 2008 in individuals 18 years of age or older, where femoral blood was available and a toxicological screening had been performed, were investigated. Genotypes were assessed with pyrosequencing and information on the cause and manner of each death was obtained from the forensic pathology and toxicology databases.Results There was a significantly higher frequency of the T allele at positions 1236, 2677, and 3435 among the suicide cases compared with the nonsuicide cases.Conclusion Our result from forensic cases suggests that ABCB1 polymorphisms are associated with an increased risk for completed suicides. The biological mechanisms involved and the clinical implications for these findings are largely unknown and need to be examined further.

Place, publisher, year, edition, pages
Lippincott, Williams and Wilkins , 2013. Vol. 23, no 9, 463-469 p.
Keyword [en]
ABCB1, autopsy, forensic material, genotype, postmortem, sex, suicide
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-97235DOI: 10.1097/FPC.0b013e328363a9bfISI: 000323220200002OAI: oai:DiVA.org:liu-97235DiVA: diva2:646170
Note

Funding Agencies|National Board of Forensic Medicine in Sweden||Swedish Research Council||Swedish Cancer Society||

Available from: 2013-09-06 Created: 2013-09-05 Last updated: 2017-12-06

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Boiso, SamuelZackrisson, Anna LenaJakobsen Falk, IngridKarlsson, LouiseCarlsson, BjörnKugelberg, FredrikAhlner, JohanHägg, StaffanGreen, Henrik

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Boiso, SamuelZackrisson, Anna LenaJakobsen Falk, IngridKarlsson, LouiseCarlsson, BjörnKugelberg, FredrikAhlner, JohanHägg, StaffanGreen, Henrik
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Division of Drug ResearchFaculty of Health SciencesClinical PharmacologyDepartment of Clinical Pharmacology
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