Evidence for Age-Dependent in Vivo Conformational Rearrangement within A beta Amyloid Deposits
2013 (English)In: ACS Chemical Biology, ISSN 1554-8929, Vol. 8, no 6, 1128-1133 p.Article in journal (Refereed) Published
Deposition of aggregated A beta peptide in the brain is one of the major hallmarks of Alzheimers disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within A beta plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
Place, publisher, year, edition, pages
American Chemical Society , 2013. Vol. 8, no 6, 1128-1133 p.
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-96432DOI: 10.1021/cb4000376ISI: 000320979300006OAI: oai:DiVA.org:liu-96432DiVA: diva2:649052
Funding Agencies|EU-FP7 Health Programme Project LUPAS||Swedish Alzheimer Foundation||Swedish Research Council||Knut and Alice Wallenberg Foundation||Swedish Foundation for Strategic Research||European Research Council (ERC)||Norwegian Research Council|183338/S10|Georg and Astrid Olsson||2013-09-172013-08-192014-04-08