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Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center of Paediatrics and Gynaecology and Obstetrics, Department of Gynaecology and Obstetrics in Linköping.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
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2013 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 43, no 9, 2361-2372 p.Article in journal (Refereed) Published
Abstract [en]

The initial interaction between HIV-1 and the host occurs at the mucosa during sexual intercourse. In cervical mucosa, HIV-1 exists both as free and opsonized virions and this might influence initial infection. We used cervical explants to study HIV-1 transmission, the effects of opsonization on infectivity, and how infection can be prevented. Complement opsonization enhanced HIV-1 infection of dendritic cells (DCs) compared with that by free HIV-1, but this increased infection was not observed with CD4+ T cells. Blockage of the α4-, β7-, and β1-integrins significantly inhibited HIV-1 infection of both DCs and CD4+ T cells. We found a greater impairment of HIV-1 infection in DCs for complement-opsonized virions compared with that of free virions when αM/β2- and α4-integrins were blocked. Blocking the C-type lectin receptor macrophage mannose receptor (MMR) inhibited infection of emigrating DCs but had no effect on CD4+ T-cell infection. We show that blocking of integrins decreases the HIV-1 infection of both mucosal DCs and CD4+ T cells emigrating from the cervical tissues. These findings may provide the basis of novel microbicidal strategies that may help limit or prevent initial infection of the cervical mucosa, thereby reducing or averting systemic HIV-1 infection.

Place, publisher, year, edition, pages
2013. Vol. 43, no 9, 2361-2372 p.
Keyword [en]
CD4+ T cells, Complement system, DCs, HIV, Integrins
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-97646DOI: 10.1002/eji.201243257ISI: 000327819200016PubMedID: 23686382OAI: oai:DiVA.org:liu-97646DiVA: diva2:649880
Available from: 2013-09-19 Created: 2013-09-19 Last updated: 2017-12-06

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Tjomsland, VeronicaEllegård, RadaKjölhede, PrebenBorendal Wodlin, NinniHinkula, JormaLarsson, Marie

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Tjomsland, VeronicaEllegård, RadaKjölhede, PrebenBorendal Wodlin, NinniHinkula, JormaLarsson, Marie
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Molecular VirologyFaculty of Health SciencesDivision of Microbiology and Molecular MedicineDivision of Clinical SciencesDepartment of Gynaecology and Obstetrics in LinköpingDepartment of Clinical and Experimental Medicine
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