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Effect of postoperative insulin-like growth factor I supplementation on protein metabolism in humans
Linköping University, Department of Biomedicine and Surgery, Division of surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Division of surgery. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Division of surgery. Linköping University, Faculty of Health Sciences.
Department of Surgery, Karolinska Institute, Stockholm, Sweden.
1995 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 82, no 7, 921-925 p.Article in journal (Refereed) Published
Abstract [en]

Insulin-like growth factor I (IGF-I) has been shown experimentally to exert a nitrogen-sparing effect in both animals and humans. Its effects on protein metabolism during the first 5 days after radical large bowel resection were investigated. Nineteen patients were randomly allocated to receive either human recombinant IGF-I (2 × 80 μ/kg body weight subcutaneously, n = 10) or placebo (n = 9) starting on the morning of the first day after operation. All patients received parenteral nutrition (glucose 3 g and nitrogen 0.1 g/kg/day). The mean(s.e.m.) urinary nitrogen: creatinine ratio was significantly reduced in patients who received IGF-I compared with those given placebo (275.0(17.1) compared with 386.3(23.6), P<0.01). The mean urinary 3-methylhistidine: creatinine ratio and nitrogen balance were lower in the IGF-I group, but not significantly so. Plasma IGF-I concentrations were four times higher in the treated group compared with those in the placebo group. Insulin-like growth factor binding protein 3 (IGFBP-3) increased significantly after the start of IGF-I treatment, compared with mean postoperative levels. The mean blood glucose concentration was significantly lower in the IGF-I group than the placebo group (P < 0.05) but no patient had a hypoglycaemic attack. The authors conclude that IGF-I does not significantly influence the nitrogen balance, but that results indicate a possible nitrogen-sparing effect in patients after major abdominal operations. IGF-I therapy is safe, and may be of value in catabolic patients after serious injury and major operations.

Place, publisher, year, edition, pages
1995. Vol. 82, no 7, 921-925 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-97710DOI: 10.1002/bjs.1800820722ISI: A1995RG57400018OAI: oai:DiVA.org:liu-97710DiVA: diva2:650234
Available from: 2013-09-20 Created: 2013-09-20 Last updated: 2017-12-06
In thesis
1. Effects of IGF-I administration to the postoperative patient
Open this publication in new window or tab >>Effects of IGF-I administration to the postoperative patient
2005 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Linköping: Kopierat själv, 2005. 39 p.
Series
Linköping Studies in Health Sciences. Thesis, ISSN 1100-6013 ; 72
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-32756 (URN)18682 (Local ID)91-85299-18-9 (ISBN)18682 (Archive number)18682 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-09-20

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Leinsköld, TedOlaison, Gunnar

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