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Fe(III) distribution varies substantially within and between atherosclerotic plaques
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Inflammation Medicine. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Diagnostics, Department of Clinical Pathology and Clinical Genetics.
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences.
Norwegian University of Science and Technology, Trondheim, Norway.
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2014 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 2, no 71, 885-892 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE:

Vulnerable atherosclerotic plaques are structurally weak and prone to rupture, presumably due to local oxidative stress. Redox active iron is linked to oxidative stress and the aim of this study was to investigate the distribution of Fe(III) in carotid plaques and its relation to vulnerability for rupture.

METHODS:

Atherosclerotic plaques from 10 patients (three asymptomatic and seven symptomatic) were investigated. Plaque vulnerability was classified using ultrasound and immunohistochemistry and correlated to Fe(III) measured by electron paramagnetic resonance spectroscopy.

RESULTS:

Large intra-plaque Fe(III) variations were found. Plaques from symptomatic patients had a higher Fe(III) concentration as compared with asymptomatic plaques (0.36 ± 0.21 vs. 0.06 ± 0.04 nmol Fe(III)/mg tissue, P < 0.05, in sections adjoining narrowest part of the plaques). All but one plaque from symptomatic patients showed signs of cap rupture. No plaque from asymptomatic patients showed signs of cap rupture. There was a significant increase in cap macrophages in plaques from symptomatic patients compared with asymptomatic patients (31 ± 11% vs. 2.3 ± 2.3%, P < 0.01).

CONCLUSION:

Fe(III) distribution varies substantially within atherosclerotic plaques. Plaques from symptomatic patients had significantly higher concentrations of Fe(III), signs of cap rupture and increased cap macrophage activity.

Place, publisher, year, edition, pages
United States: John Wiley & Sons, 2014. Vol. 2, no 71, 885-892 p.
Keyword [en]
atherosclerosis; oxidative stress; reactive oxygen species; iron; electron paramagnetic resonance
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:liu:diva-98001DOI: 10.1002/mrm.24687ISI: 000330769700047PubMedID: 23447110OAI: oai:DiVA.org:liu-98001DiVA: diva2:651081
Available from: 2013-09-24 Created: 2013-09-24 Last updated: 2017-12-06

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Gustafsson, HåkanHallbeck, MartinEngström, MariaRosén, AndersZachrisson, Helene

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Gustafsson, HåkanHallbeck, MartinEngström, MariaRosén, AndersZachrisson, Helene
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Center for Medical Image Science and Visualization (CMIV)Division of Radiological SciencesFaculty of Health SciencesDivision of Inflammation MedicineDepartment of Clinical Pathology and Clinical GeneticsDivision of Cardiovascular MedicineDivision of Cell BiologyDepartment of Clinical Physiology in Linköping
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