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Neutrophil control of formylmethionyl-leucyl-phenylalanine induced mobilization of secretory vesicles and NADPH-oxidase activation: Effect of an association of the ligand-receptor complex to the cytoskeleton
Phagocyte Research Laboratory, Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden.
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0002-3756-207X
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Molecular and Clinical Medicine, Medical Microbiology. Linköping University, Faculty of Health Sciences.
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1994 (English)In: Biochimica et Biophysica Acta. Molecular Cell Research, ISSN 0167-4889, E-ISSN 1879-2596, Vol. 1224, no 1, 43-50 p.Article in journal (Refereed) Published
Abstract [en]

The stimulus formylmethionyl-leucyl-phenylalanine (FMLP) interacts with neutrophils and generates signal(s) in the cells that induces mobilization of the secretory vesicles as well as activation of the superoxide anion/hydrogen peroxide generating NADPH-oxidase. Binding, at 15°C, of FMLP to its neutrophil surface receptor is followed by an association of the ligand-receptor complex to the cell cytoskeleton, and this association occurs concomitant with a desensitization of the cells with respect to activation of the NADPH-oxidase. Other stimuli can still activate the oxidase (in fact even induce a primed response), indicating that the observed phenomenon is stimulus specific and could not be accounted for by an effect on the oxidase itself, but rather that the association of the ligand-receptor complex to the cytoskeleton eliminates the capacity of the complex to generate the signal(s) that activates the NADPH-oxidase. The cytoskeleton associated ligand-receptor complex generates, however, the signal(s) responsible for mobilization of the secretory vesicles, to the plasma membrane, and this mobilization occurs without any increase in the intracellular concentration of free Ca2+.

Place, publisher, year, edition, pages
Elsevier, 1994. Vol. 1224, no 1, 43-50 p.
Keyword [en]
Cytoskeleton; NADPH-oxidase; Secretory vesicle; Desensitization; Signal transduction; Calcium ion, intracellular; (Leukocyte)
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-98035DOI: 10.1016/0167-4889(94)90111-2ISI: A1994PP07100007PubMedID: 7948041OAI: oai:DiVA.org:liu-98035DiVA: diva2:651368
Available from: 2013-09-25 Created: 2013-09-25 Last updated: 2017-12-06Bibliographically approved

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Gustafsson, MikaelSärndahl, Eva

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