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Quantitative hypoxia imaging for treatment planning of radiotherapy
Stockholm University and Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-7101-240X
Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Radiation Physics. Linköping University, Faculty of Health Sciences. Linköping University, Department of Medical and Health Sciences, Division of Radiological Sciences.ORCID iD: 0000-0001-8171-2541
2014 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, Vol. 812, 143-148 p.Article in journal (Refereed) Published
Abstract [en]

Tumour oxygenation is an important determinant of radiotherapy outcome as it could modulate cellular radiation sensitivity. Advanced PET imaging able to characterise this microenvironmental aspect in vivo might be used to devise counteracting therapies as it could provide information on the severity and the spatial distribution of the hypoxic regions. This study reviews the advantages and limitations of PET for imaging and quantifying tumour hypoxia and proposes a novel approach to obtain absolute levels of hypoxia from PET images through the use of EPR oximetry. This would offer a significant advantage over proposals based on empirical conversions of the intensities in the PET images to relative radiosensitivities. Thus, tumour hypoxia must be taken into account at the stage of treatment planning for photons and particle therapy by accounting for its extent and severity through the use of PET imaging combined with absolute EPR measurements.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 812, 143-148 p.
Keyword [en]
PET imaging, tumour hypoxia, oxygenation, treatment planning, treatment optimization
National Category
Cancer and Oncology
URN: urn:nbn:se:liu:diva-98063DOI: 10.1007/978-1-4939-0620-8_19ISI: 000345121200020OAI: diva2:651734
Available from: 2013-09-27 Created: 2013-09-27 Last updated: 2015-05-07

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Toma-Dasu, IulianaDasu, Alexandru
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Department of Radiation PhysicsFaculty of Health SciencesDivision of Radiological Sciences
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