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Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Linköping University, Department of Medical and Health Sciences, Division of Cardiovascular Medicine. Linköping University, Faculty of Health Sciences. Karolinska Institute, Sweden .
2013 (English)In: Trends in Molecular Medicine, ISSN 1471-4914, E-ISSN 1471-499X, Vol. 19, no 8, 460-473 p.Article, review/survey (Refereed) Published
Abstract [en]

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently expressed in various tumors and their expression levels correlate with tumor growth, invasiveness, drug resistance, and poor clinical outcomes. Emerging experimental evidence demonstrates that PDGFs exhibit multiple functions in modulation of tumor growth, metastasis, and the tumor microenvironment by targeting malignant cells, vascular cells, and stromal cells. Understanding PDGF PDGFR-mediated molecular signaling may provide new mechanistic rationales for optimizing current cancer therapies and the development of future novel therapeutic modalities.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 19, no 8, 460-473 p.
Keyword [en]
PDGF, tumor growth, metastasis, tumor microenvironment, targeted therapy
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-98152DOI: 10.1016/j.molmed.2013.05.002ISI: 000323795600003OAI: diva2:652283

Funding Agencies|Swedish Research Council||Swedish Cancer Foundation||Karolinska Institute Foundation||Karolinska Institute Distinguished Professor Award||Torsten Soderbergs Foundation, Soderbergs Stiftelse||ImClone Systems/EliLilly||Tianjin Municipal Science and Technology Commission Research Fund|09ZCZDSF04400|European Union Integrated Project of Metoxia|222741|European Research Council (ERC) advanced grant ANGIOFAT|250021|

Available from: 2013-09-30 Created: 2013-09-30 Last updated: 2013-09-30

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Cao, Yihai
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