liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
The international normalized ratio according to Owren in liver disease: Interlaboratory assessment and determination of international sensitivity index
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Karolinska University Hospital, Sweden .
Show others and affiliations
2013 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 132, no 3, 346-351 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: The international normalized ratio (INR) is used to prioritize liver disease patients for transplantation. Previous studies have shown high interlaboratory variability in Quick-based INR determinations in samples of patients with liver disease. We assessed Owren-based INR reagents for analyzing INR in patients with liver disease. Further, we determined the difference between international sensitivity index (ISI) for patients on vitamin K antagonists (ISIVKA) and ISI for patients with liver disease (ISIliver). less thanbrgreater than less thanbrgreater thanPatients and Methods: Twenty patients with liver disease were included, 10 with INR 1.8-3.6 (group A1) and 10 with INR 1.2-1.5 (group C1). Plasma from these patients was analyzed for Owren-based INR in eight Swedish laboratories using either of following reagents: SPA+, Owrens PT or Nycotest PT. To determine ISI liver, the reference thromboplastin RBT/05 and additional 41 patients with liver disease and 20 normal controls were included. ISIVKA was determined according to the WHO procedure. The difference between the ISIVKA and ISIliver was calculated. less thanbrgreater than less thanbrgreater thanResults: The coefficients of variance for the Owren based INR methods were 6.2% in group A1, 3.9 % in group C1 and 5.3% for all patients. The difference between ISIVKA and ISIliver were -0.4%, -0.7% and -0.2% for SPA+, Owrens PT and Nycotest PT respectively. less thanbrgreater than less thanbrgreater thanConclusions: Interlaboratory variation in INR analyses according to Owren in patients with liver disease is low and the difference between ISIVKA and ISIliver is below 10% with this method. ISIVKA can therefore be used in the INR calibration, for the Owren reagents studied, when analyzing plasma from patients with liver disease.

Place, publisher, year, edition, pages
Elsevier , 2013. Vol. 132, no 3, 346-351 p.
Keyword [en]
INR, Prothrombin time, Liver disease, Liver transplantation, Severity of illness index, MELD
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-98222DOI: 10.1016/j.thromres.2013.05.032ISI: 000324060400009OAI: diva2:653214

Funding Agencies|Swedish Order of Freemasons||Samariten Foundation||Wera Ekstrom Foundation||Ronald McDonald House Charities||HRH Crownprincess Lovisa Foundation||Foundation for Childrens Hospital Huddinge||Foundation of Clinical Research at Karolinska Institutet||Swedish Society of Medicine||Foundation of Coagulation research at Karolinska Institutet||Sven Jerring Foundation||Lions research fund||Swedish Gastrointestinal Research Foundation||

Available from: 2013-10-03 Created: 2013-10-03 Last updated: 2014-02-17

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Kechagias, StergiosLindahl, Tomas
By organisation
Division of Cardiovascular MedicineFaculty of Health SciencesDepartment of GastroentorologyDivision of Microbiology and Molecular MedicineDepartment of Clinical Chemistry
In the same journal
Thrombosis Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 91 hits
ReferencesLink to record
Permanent link

Direct link