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Effect of metabolic presbyacusis on cochlear responses: A simulation approach using a physiologically-based model
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Technical Audiology. Linköping University, Faculty of Health Sciences.ORCID iD: 0000-0003-3350-8997
2013 (English)In: Journal of the Acoustical Society of America, ISSN 0001-4966, E-ISSN 1520-8524, Vol. 134, no 4, 2833-2851 p.Article in journal (Refereed) Published
Abstract [en]

In the presented model, electrical, acoustical, and mechanical elements of the cochlea are explicitly integrated into a signal transmission line where these elements convey physiological interpretations of the human cochlear structures. As a result, this physiologically-motivated model enables simulation of specific cochlear lesions such as presbyacusis. The hypothesis is that high-frequency hearing loss in older adults may be due to metabolic presbyacusis whereby age-related cellular/chemical degenerations in the lateral wall of the cochlea cause a reduction in the endocochlear potential. The simulations quantitatively confirm this hypothesis and emphasize that even if the outer and inner hair cells are totally active and intact, metabolic presbyacusis alone can significantly deteriorate the cochlear functionality. Specifically, in the model, as the endocochlear potential decreases, the transduction mechanism produces less receptor current such that there is a reduction in the battery of the somatic motor. This leads to a drastic decrease in cochlear amplification and frequency sensitivity, as well as changes in position-frequency map (tuning pattern) of the cochlea. In addition, the simulations show that the age-related reduction of the endocochlear potential significantly inhibits the firing rate of the auditory nerve which might contribute to the decline of temporal resolution in the aging auditory system.

Place, publisher, year, edition, pages
Acoustical Society of America (ASA), 2013. Vol. 134, no 4, 2833-2851 p.
National Category
Otorhinolaryngology Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-98271DOI: 10.1121/1.4820788ISI: 000330119700039OAI: oai:DiVA.org:liu-98271DiVA: diva2:653888
Funder
Swedish Research Council
Available from: 2013-10-07 Created: 2013-10-07 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
Open this publication in new window or tab >>Effects of Specific Cochlear Pathologies on the Auditory Functions: Modelling, Simulations and Clinical Implications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

A hearing impairment is primarily diagnosed by measuring the hearing thresholds at a range of auditory frequencies (air-conduction audiometry). Although this clinical procedure is simple, affordable, reliable and fast, it does not offer differential information about origins of the hearing impairment. The main goal of this thesis is to quantitatively link specific cochlear pathologies to certain changes in the spectral and temporal characteristics of the auditory system. This can help better understand the underlying mechanisms associated with sensorineural hearing impairments, beyond what is shown in the audiogram. Here, an electromechanical signal-transmission model is devised in MATLAB where the parameters of the model convey biological interpretations of mammalian cochlear structures. The model is exploited to simulate the cell-level cochlear pathologies associated with two common types of sensorineural hearing impairments, 1: presbyacusis (age-related hearing impairment) and, 2: noise-induced hearing impairment. Furthermore, a clinical study, consisting of different psychoacoustic and physiological tests, was performed to trace and validate the model predictions in human. The results of the clinical tests were collated and compared with the model predictions, showing a reasonable agreement. In summary, the present model provides a biophysical foundation for simulating the effect of specific cellular lesions, due to different inner-ear diseases and external insults, on the entire cochlear mechanism and thereby on the whole auditory system. This is a multidisciplinary work in the sense that it connects the ‘biological processes’ with ‘acoustic modelling’ and ‘clinical audiology’ in a translational context.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2014. 57 p.
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1400Studies from the Swedish Institute for Disability Research, ISSN 1650-1128 ; 60
Keyword
Auditory modeling, cochlear mechanics, sensorineural hearing impairment, age-related hearing loss, noise-induced hearing loss, inner ear pathologies
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-105810 (URN)10.3384/diss.diva-105810 (DOI)978-91-7519-365-6 (ISBN)
Public defence
2014-04-28, Nils Holger salen, entrance 71, Campus US, Linköpings universitet, Linköping, 13:00 (English)
Opponent
Supervisors
Available from: 2014-04-08 Created: 2014-04-08 Last updated: 2014-10-08Bibliographically approved

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Saremi, AminStenfelt, Stefan

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