In this thesis, a resource allocation problem in OFDMA is studied for the energy efficiency of wireless network. The objective is to minimize the total energy consumption which includes transmission energy consumption, and circuit energy consumption at both transmitter and receiver with required per user’s rate constraint. For problem solution, a heuristic algorithm with low computational complexity and suboptimal solution is proposed, developed in two steps with an increasing order of complexity. Besides, a bounding scheme based on model linearization of formulated nonlinear system model is also proposed to give lower and upper bounds for both small- and large-scale OFDMA network for further algorithm performance evaluation, while the implemented exhaustive search is only capable to provide the optimal solution for small-scale instance for algorithm performance evaluation. Numerical results show that the proposal heuristic algorithm can achieve near-optimal performance with applicable computational complexity even for large-scale networks, and that the bounds from the bounding scheme are very tight for both small- and large-scale OFDMA networks.