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Impact of Dye-Protein Interaction and Silver Nanoparticles on Rose Bengal Photophysical Behavior and Protein Photocrosslinking
University of Ottawa, ON, Canada.
Center for Bioinformatics and Molecular Simulation, Universidad de Talca, Chile.
Linköping University, Department of Clinical and Experimental Medicine, Division of Cell Biology. Linköping University, Faculty of Health Sciences. University of Ottawa Eye Institute, ON, Canada.ORCID iD: 0000-0003-1222-6720
University of Ottawa, ON, Canada.
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2013 (English)In: Photochemistry and Photobiology, ISSN 0031-8655, E-ISSN 1751-1097, Vol. 89, no 6, 1433-1441 p.Article in journal (Refereed) Published
Abstract [en]

The role of recombinant Type-I human collagen in the free form or forming AgNP@collagen on the photophysical and photochemical behavior of rose Bengal was analyzed. The formation of dye aggregates on the protein surface was experimentally observed and corroborated by docking calculations. The formation of such aggregates is believed to change the main oxidative mechanism from Type-II (singlet oxygen) to Type-I (free radical) photosensitization. Remarkably, the presence of AgNP in the form of AgNP@collagen altered the dynamics of dye triplet deactivation, effectively preventing the dye degradation and reducing the extent of protein crosslinked. Both crosslinked rHC and AgNP@collagen were able to support fibroblasts proliferation, but only the material containing silver was resistant to S. epidermidis infection.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013. Vol. 89, no 6, 1433-1441 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-98697DOI: 10.1111/php.12119ISI: 000326507100023PubMedID: 23799987OAI: diva2:655389
Available from: 2013-10-11 Created: 2013-10-11 Last updated: 2013-12-17

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Griffith, MayScaiano, Juan C.
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