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Controlled release of bevacizumab through nanospheres for extended treatment of age-related macular degeneration.
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada / University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada.
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada / University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada.
Centre for Catalysis Research and Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.
Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada / University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H8L6, Canada.
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2012 (English)In: The open ophthalmology journal, ISSN 1874-3641, Vol. 6, 54-8 p.Article in journal (Refereed) Published
Abstract [en]

Bevacizumab (Avastin(®)) has been used by ophthalmologists in many countries as an off-label drug for the treatment of wet age-related macular degeneration (AMD). Due to its short half-life necessitating frequent intravitreal injection, a method for sustained delivery is in need. We demonstrated that bevacizumab could be released in a sustained fashion over 90 days from nano- and microspheres fabricated from poly(DL-lactide-co-glycolide) and poly(ethylene glycol)-b-poly(D,L-lactic acid), respectively. The drug release rate could be adjusted by alteration of the drug/polymer ratio. The use of such nano- and microspheres as bevacizumab delivery vehicles may improve the treatment of wet AMD.

Place, publisher, year, edition, pages
Bentham open , 2012. Vol. 6, 54-8 p.
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:liu:diva-98705DOI: 10.2174/1874364101206010054PubMedID: 22798970OAI: oai:DiVA.org:liu-98705DiVA: diva2:655463
Available from: 2013-10-11 Created: 2013-10-11 Last updated: 2017-01-17

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Griffith, May

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