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Preconditioning enhances the expression of mitochondrial antioxidant thioredoxin-2 in the forebrain of rats exposed to severe hypobaric hypoxia
Tampere University Medical School, and Tampere University Hospital, Finland .
Pavlov Institute of Physiology, RAS, St. Petersburg, Russia.
Pavlov Institute of Physiology, RAS, St. Petersburg, Russia.
Department of Biosciences, Karolinska Institute, Huddinge, Sweden.
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2004 (English)In: Journal of Neuroscience Research, ISSN 0360-4012, E-ISSN 1097-4547, Vol. 78, no 4, 563-569 p.Article in journal (Refereed) Published
Abstract [en]

The impact of severe hypoxia and preconditioning on the expression of the mitochondrial antioxidant thioredoxin-2 (Trx-2) in rat hippocampus (CA1, CA2, CA3 fields, and dentate gyrus) and neocortex was studied by immunocytochemistry. The preconditioning consisted of three trials of mild hypobaric hypoxia (360 Torr, 2 hr) spaced at 24 hr. The last trial was followed by severe hypobaric hypoxia (180 Torr, 3 hr) 24 hr later. Both in hippocampus and in neocortex, severe hypobaric hypoxia resulted in enhanced Trx-2 expression at 3 hr, followed by a slight decline in Trx-2 levels, which nevertheless remained increased at 24 hr elsewhere except for the CA1 region. The preconditioning considerably augmented severe hypoxia-induced Trx-2 immunoreactivity, affecting both the number of immunoreactive cells and the intensity of immunostaining. The findings suggest a role for Trx-2 in the formation of brain hypoxic/ischemic tolerance accomplished by the preconditioning.

Place, publisher, year, edition, pages
John Wiley & Sons, 2004. Vol. 78, no 4, 563-569 p.
Keyword [en]
thioredoxin-2; brain; hypobaric hypoxia; preconditioning; hypoxic/ischemic tolerance
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-98789DOI: 10.1002/jnr.20282PubMedID: 15468176OAI: diva2:655881
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2013-10-23Bibliographically approved

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Spyrou, Giannis
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