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Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein
Karolinska Institute, Huddinge, Sweden.
Karolinska Institute, Huddinge, Sweden.
Karolinska Institute, Huddinge, Sweden.
1998 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 243, no 1, 284-288 p.Article in journal (Refereed) Published
Abstract [en]

This report describes the cloning of a human cDNA that encodes a new protein (Txl, Thioredoxin-like) that belongs to the expanding family of thioredoxins based on sequence comparison of the deduced amino acid sequence. This cDNA, with a total length of 1,278 bp, consists of 205 bp of 5'-untranslated sequence (including an in frame stop codon), an open reading frame of 870 bp and a 203 bp fragment of 3'-untranslated sequence. The coding sequence predicts a protein of 289 amino acids with two distinct domains: an N-terminal domain of 105 residues homologous to the rest of mammalian thioredoxins containing the conserved active site (CGPC) and a C-terminal domain of 184 residues with no homology with any other protein in the database. Northern blot analysis indicates that the txl probe hybridizes to a 1.3 Kb mRNA and is ubiquitously expressed in human tissues with the highest expression in stomach, testis and bone marrow.

Place, publisher, year, edition, pages
Elsevier, 1998. Vol. 243, no 1, 284-288 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-98835DOI: 10.1006/bbrc.1997.8003PubMedID: 9473519OAI: oai:DiVA.org:liu-98835DiVA: diva2:655978
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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