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Molecular cloning and expression of a cDNA encoding a human thioredoxin-like protein
Karolinska Institute, Huddinge, Sweden.
Karolinska Institute, Huddinge, Sweden.
Karolinska Institute, Huddinge, Sweden.
1998 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 243, no 1, p. 284-288Article in journal (Refereed) Published
Abstract [en]

This report describes the cloning of a human cDNA that encodes a new protein (Txl, Thioredoxin-like) that belongs to the expanding family of thioredoxins based on sequence comparison of the deduced amino acid sequence. This cDNA, with a total length of 1,278 bp, consists of 205 bp of 5'-untranslated sequence (including an in frame stop codon), an open reading frame of 870 bp and a 203 bp fragment of 3'-untranslated sequence. The coding sequence predicts a protein of 289 amino acids with two distinct domains: an N-terminal domain of 105 residues homologous to the rest of mammalian thioredoxins containing the conserved active site (CGPC) and a C-terminal domain of 184 residues with no homology with any other protein in the database. Northern blot analysis indicates that the txl probe hybridizes to a 1.3 Kb mRNA and is ubiquitously expressed in human tissues with the highest expression in stomach, testis and bone marrow.

Place, publisher, year, edition, pages
Elsevier, 1998. Vol. 243, no 1, p. 284-288
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-98835DOI: 10.1006/bbrc.1997.8003PubMedID: 9473519OAI: oai:DiVA.org:liu-98835DiVA, id: diva2:655978
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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