liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Selenite and selenate inhibit human lymphocyte growth via different mechanisms
Karolinska Institutet, Stockholm, Sweden. .
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet, Stockholm, Sweden.
1996 (English)In: Cancer Research, ISSN 0008-5472, E-ISSN 1538-7445, Vol. 56, no 19, 4407-4412 p.Article in journal (Refereed) Published
Abstract [en]

Selenium compounds like selenite and selenate have strong inhibitory effects, particularly on mammalian tumor cell growth by unknown mechanisms. We found that the addition of sodium selenite and sodium selenate inhibited the growth of human 3B6 and BL41 lymphocytes. Selenite was more potent because 10 microM selenite produced a growth inhibitory effect similar to that of 250 microM selenate. The mechanism of action of selenite and selenate appears to be different. 3B6 and BL41 cells treated with selenite accumulated in the S-phase; however, selenate caused an accumulation of cells in G2. Selenite-mediated growth inhibition was irreversible, although the effects of selenate could be reversed. Selenite, in contrast to selenate, is efficiently reduced by the thioredoxin system (thioredoxin, thioredoxin reductase, and NADPH). At concentrations required to observe a similar effect on cell growth, the activity of thioredoxin reductase, recently shown to be a selenoprotein, increased in selenite-treated cells and decreased in selenate-treated cells. Ribonucleotide reductase activity was inhibited in an in vitro assay by selenite and selenodiglutathione but not by selenate. These results show that selenite and selenate use different mechanisms to inhibit cell growth.

Place, publisher, year, edition, pages
American Association for Cancer Research , 1996. Vol. 56, no 19, 4407-4412 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-98846PubMedID: 8813134OAI: diva2:655996
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2013-10-22Bibliographically approved

Open Access in DiVA

No full text

Other links

PubMedLink to article

Search in DiVA

By author/editor
Spyrou, Giannis
In the same journal
Cancer Research
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link