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Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells
Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA.
Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA.
Department of Biosciences at Novum, Center for Biotechnology, Karolinska Institutet, Huddinge, Sweden.
Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Boston, Massachusetts, USA.
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1994 (English)In: Immunity, ISSN 1074-7613, E-ISSN 1097-4180, Vol. 1, no 1, 65-72 p.Article in journal (Refereed) Published
Abstract [en]

To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells resulted in normal levels of proliferation and immunoglobulin secretion. Likewise, stimulation of c-jun-/- T cells resulted in essentially normal levels of IL-2R alpha expression, IL-2 secretion, and proliferation. We further showed that the relatively normal activation responses of the c-jun-/- T cells probably results from the fact that other members of the Jun family contribute to the bulk of the activator protein-1 (AP-1) complexes in normal T cells and, as a result, AP-1 complexes are found at relatively normal levels in c-jun-/- T cells.

Place, publisher, year, edition, pages
Cell Press , 1994. Vol. 1, no 1, 65-72 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-98854PubMedID: 7889400OAI: oai:DiVA.org:liu-98854DiVA: diva2:656006
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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