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Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
Département des Biotechnologies, Institut Pasteur, Paris, France.
Département des Biotechnologies, Institut Pasteur, Paris, France.
Département des Biotechnologies, Institut Pasteur, Paris, France.
Département des Biotechnologies, Institut Pasteur, Paris, France.
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1994 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 76, no 4, 747-760 p.Article in journal (Refereed) Published
Abstract [en]

As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in G0/G1 while c-Jun overexpression produces larger S/G2 and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two closely related transcription factors can function in an opposing manner.

Place, publisher, year, edition, pages
Cell Press , 1994. Vol. 76, no 4, 747-760 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-98855PubMedID: 8124713OAI: oai:DiVA.org:liu-98855DiVA: diva2:656008
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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