Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras
1994 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 76, no 4, 747-760 p.Article in journal (Refereed) Published
As NIH 3T3 fibroblasts become quiescent, the level of c-Jun protein decreases while JunD accumulates. When resting cells are stimulated with fresh serum, nuclear-localized JunD is rapidly degraded, followed by resynthesis of both c-Jun and JunD later in G1. Overexpression of JunD results in slower growth and an increase in the percentage of cells in G0/G1 while c-Jun overexpression produces larger S/G2 and M phase populations. In addition, JunD partially suppresses transformation by an activated ras gene whereas c-Jun cooperates with ras to transform cells. These data indicate that two closely related transcription factors can function in an opposing manner.
Place, publisher, year, edition, pages
Cell Press , 1994. Vol. 76, no 4, 747-760 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-98855PubMedID: 8124713OAI: oai:DiVA.org:liu-98855DiVA: diva2:656008