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Unregulated expression of c-Jun or c-Fos proteins but not Jun D inhibits oestrogen receptor activity in human breast cancer derived cells
Département des Biotechnologies, Institut Pasteur, Paris, France.
Département des Biotechnologies, Institut Pasteur, Paris, France.
Département des Biotechnologies, Institut Pasteur, Paris, France.
1991 (English)In: EMBO Journal, ISSN 0261-4189, E-ISSN 1460-2075, Vol. 10, no 8, 2237-2245 p.Article in journal (Refereed) Published
Abstract [en]

We present evidence that oestrogen receptor activity in human MCF-7 breast cancer cells is reduced by over-expression of c-Jun or c-Fos proteins and to a lesser extent by Jun B overexpression. In contrast, overexpression of Jun D protein does not affect the activity of the oestrogen receptor. A region of c-Jun found to be required for repression of oestrogen receptor activity is located outside the DNA binding domain and is not conserved among the three Jun proteins. Finally, we suggest that c-Jun and c-Fos act independently to inactivate the oestrogen receptor.

Place, publisher, year, edition, pages
Wiley-Blackwell, 1991. Vol. 10, no 8, 2237-2245 p.
Keyword [en]
c-Jun/c-Fos/Jun D/oestrogen receptor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-98859PubMedID: 1906001OAI: oai:DiVA.org:liu-98859DiVA: diva2:656012
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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