Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors
1988 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 155, no 2, 923-929 p.Article in journal (Refereed) Published
Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e. incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.
Place, publisher, year, edition, pages
Elsevier, 1988. Vol. 155, no 2, 923-929 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-98864PubMedID: 3421973OAI: oai:DiVA.org:liu-98864DiVA: diva2:656015