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Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors
Semmelweis University Medical School, Budapest, Hungary.
Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden.
Semmelweis University Medical School, Budapest, Hungary.
1988 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 155, no 2, 923-929 p.Article in journal (Refereed) Published
Abstract [en]

Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e. incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.

Place, publisher, year, edition, pages
Elsevier, 1988. Vol. 155, no 2, 923-929 p.
National Category
Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-98864PubMedID: 3421973OAI: oai:DiVA.org:liu-98864DiVA: diva2:656015
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Spyrou, Giannis

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