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Fluorescence spectroscopy using indocyanine green for lymph node mapping
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0555-8877
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology. University of Applied Sciences in Northwest Switzerland.
Linköping University, Department of Clinical and Experimental Medicine, Division of Clinical Sciences. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Center for Surgery, Orthopaedics and Cancer Treatment, Department of Surgery in Linköping.
Linköping University, Department of Biomedical Engineering, Biomedical Instrumentation. Linköping University, The Institute of Technology. (MINT)ORCID iD: 0000-0002-0012-7867
2014 (English)In: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, E-ISSN 1996-756X, ISSN 0277-786X, Vol. 8935, no 893504, 1-6 p.Article in journal (Refereed) Published
Abstract [en]

The principles of cancer treatment has for years been radical resection of the primary tumor. In the oncologic surgeries where the affected cancer site is close to the lymphatic system, it is as important to detect the draining lymph nodes for metastasis (lymph node mapping). As a replacement for conventional radioactive labeling, indocyanine green (ICG) has shown successful results in lymph node mapping; however, most of the ICG fluorescence detection techniques developed are based on camera imaging. In this work, fluorescence spectroscopy using a fiber-optical probe was evaluated on a tissue-like ICG phantom with ICG concentrations of 6-64 μM and on breast tissue from five patients. Fiber-optical based spectroscopy was able to detect ICG fluorescence at low intensities; therefore, it is expected to increase the detection threshold of the conventional imaging systems when used intraoperatively. The probe allows spectral characterization of the fluorescence and navigation in the tissue as opposed to camera imaging which is limited to the view on the surface of the tissue

Place, publisher, year, edition, pages
2014. Vol. 8935, no 893504, 1-6 p.
Keyword [en]
Intra-operative optical imaging, near infrared fluorescence, breast cancer surgery, optical phantom, optimal ICG concentration, spectroscopy
National Category
Medical Engineering
Identifiers
URN: urn:nbn:se:liu:diva-98988DOI: 10.1117/12.2036765ISI: 000335493700002ISBN: 9780819498489 (print)OAI: oai:DiVA.org:liu-98988DiVA: diva2:656050
Conference
Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XII, 2-4 February 2014, San Francisco, California, USA
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2017-12-06Bibliographically approved

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Haj-Hosseini, NedaShabo, IvanWårdell, Karin

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Biomedical InstrumentationThe Institute of TechnologyDepartment of Biomedical EngineeringDivision of Clinical SciencesFaculty of Health SciencesDepartment of Surgery in Linköping
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Proceedings of SPIE, the International Society for Optical Engineering
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