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Kidney function after in vivo gene silencing of uncoupling protein-2 in streptozotocin-induced diabetic rats.
Division of Integrative Physiology, Department of Medical Cell Biology, Biomedical Center, Uppsala University.
Division of Nephrology and Hypertension, Department of Medicine, Medical Center, Georgetown University.
Division of Nephrology and Hypertension, Department of Medicine, Medical Center, Georgetown University.
Linköping University, Department of Medical and Health Sciences, Division of Drug Research. Linköping University, Faculty of Health Sciences. Divion of Integrative Physiology, Department of Medical Cell Biology, Biomedical Center, Uppsala University. Division of Nephrology and Hypertension, Department of Medicine, Medical Center, Georgetown University.
2013 (English)In: Advances in Experimental Medicine and Biology, ISSN 0065-2598, E-ISSN 2214-8019, Vol. 765, 217-223 p.Article in journal (Refereed) Published
Abstract [en]

Kidney uncoupling protein 2 (UCP-2) increases in streptozotocin-induced diabetes, resulting in mitochondria uncoupling, i.e., increased oxygen consumption unrelated to active transport. The present study aimed to investigate the role of UCP-2 for normal and diabetic kidney function utilizing small interference RNA (siRNA) to reduce protein expression. Diabetic animals had increased glomerular filtration rate and kidney oxygen consumption, resulting in decreased oxygen tension and transported sodium per consumed oxygen. UCP-2 protein levels decreased 2 and 50% after UCP-2 siRNA administration in control and diabetic animals respectively. Kidney function was unaffected by in vivo siRNA-mediated gene silencing of UCP-2. The reason for the lack of effect of reducing UCP-2 is presently unknown but may involve compensatory mitochondrial uncoupling by the adenosine nucleotide transporter.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2013. Vol. 765, 217-223 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-99425DOI: 10.1007/978-1-4614-4989-8_30ISI: 000339280100031PubMedID: 22879036OAI: oai:DiVA.org:liu-99425DiVA: diva2:656973
Available from: 2013-10-17 Created: 2013-10-17 Last updated: 2017-12-06

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Palm, Fredrik

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