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Critical issues in translational and clinical research for the study of new technologies to enhance bone repair
Schulthess Klinik, Zurich, Switzerland.
Eli Lilly and Company, Indianapolis, IN, USA.
Linköping University, Department of Neuroscience and Locomotion, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
University of Sheffield Medical School, UK.
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2008 (English)In: Journal of Bone and Joint Surgery. American volume, ISSN 0021-9355, E-ISSN 1535-1386, Vol. 90, no Supplement 1, 43-47 p.Article in journal (Refereed) Published
Abstract [en]

Osteoporosis increases fracture risk, especially in metaphyseal bone. Fractures seriously impair function and quality of life and incur large direct and indirect costs. Although the prevention of fractures is certainly the option, a fast and uneventful healing process is optimal when fractures do occur. Many new therapeutic strategies have been developed to accelerate fracture-healing or to diminish the complication rate during the course of fracture-healing. However, widely accepted guidelines are needed to demonstrate the positive or negative interactions of bioactive substances, drugs, and other agents that are being used to promote fracture-healing. For each study design, the primary study goal should be indicated. Outcome variables should include both objective and subjective parameters. The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements.

Place, publisher, year, edition, pages
Journal of Bone and Joint Surgery , 2008. Vol. 90, no Supplement 1, 43-47 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-99518DOI: 10.2106/JBJS.G.01090PubMedID: 18292356OAI: diva2:657332
Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2013-10-28Bibliographically approved

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Aspenberg, Per
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Orthopaedics and Sports MedicineFaculty of Health Sciences
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