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Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences. Malmö University Hospital, Malmö, Sweden.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine. Linköping University, Faculty of Health Sciences.
2009 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 80, no 6, 693-703 p.Article, review/survey (Refereed) Published
Abstract [en]

Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.

Place, publisher, year, edition, pages
London, UK: Informa Healthcare, 2009. Vol. 80, no 6, 693-703 p.
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Orthopedics
Identifiers
URN: urn:nbn:se:liu:diva-99583DOI: 10.3109/17453670903448257ISI: 000272611900012PubMedID: 19968600OAI: oai:DiVA.org:liu-99583DiVA: diva2:657349
Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2017-12-06Bibliographically approved

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Pasternak, BjörnAspenberg, Per

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