Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics.
2009 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 80, no 6, 693-703 p.Article in journal (Refereed) Published
Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their inhibitors control matrix turnover and function. Recent advances in our understanding of musculoskeletal conditions such as tendinopathy, arthritis, Dupuytren's disease, degenerative disc disease, and bone and soft tissue healing suggest that MMPs have prominant roles. Importantly, MMPs are amenable to inhibition by cheap, safe, and widely available drugs such as the tetracycline antibiotics and the bisphosphonates. This indicates that these MMP inhibitors, if proven effective for any novel indication, may be quickly brought into clinical practice.
Place, publisher, year, edition, pages
London, UK: Informa Healthcare, 2009. Vol. 80, no 6, 693-703 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-99583DOI: 10.3109/17453670903448257ISI: 000272611900012PubMedID: 19968600OAI: oai:DiVA.org:liu-99583DiVA: diva2:657349