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Bacterial protein toxins targeting rho GTPases
Institut für Pharmakologie und Toxikologie der Universita«t Freiburg, Germany.
Institut für Pharmakologie und Toxikologie der Universita«t Freiburg, Germany.
Institut für Pharmakologie und Toxikologie der Universita«t Freiburg, Germany.
2000 (English)In: FEMS Microbiology Letters, ISSN 0378-1097, E-ISSN 1574-6968, Vol. 188, no 1, 1-6 p.Article in journal (Refereed) Published
Abstract [en]

Several bacterial protein toxins target eukaryotic cells by modulating the functions of Rho GTPases that are involved in various signal processes and in the regulation of the actin cytoskeleton. The toxins inhibit Rho functions by ADP-ribosylation or glucosylation and activate them by deamidation and transglutamination. New findings indicate that the GTPases are also targeted by various 'injected' toxins which are introduced into the eukaryotic cells by the type-III secretion system. The injected toxins do not covalently modify Rho GTPases, but manipulate their regulatory GTPase cycle by acting as GTPase-activating proteins or guanine nucleotide exchange factors.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2000. Vol. 188, no 1, 1-6 p.
Keyword [en]
Rho GTPase; Toxin; Glucosylation; Type-III secretion; ADP-ribosylation; Clostridium di¤cile toxin; Deamidation; Transglutamination; Cytotoxic necrotising factor
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-99619DOI: 10.1111/j.1574-6968.2000.tb09159.xPubMedID: 10867225OAI: oai:DiVA.org:liu-99619DiVA: diva2:657390
Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2017-12-06Bibliographically approved

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Lerm, Maria

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