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Characterization of the lipid and protein contents of myelin bodies isolated from the renal cortex of gentamicin-treated rats
Karolinska Institutet, Huddinge Hospital, Sweden.
Arrhenius Laboratory for the Natural Sciences, Stockholm University, Sweden.ORCID iD: 0000-0003-3927-4394
Stockholm University, Sweden.
Stockholm University, Sweden.
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1991 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 181, no 2, 894-901 p.Article in journal (Refereed) Published
Abstract [en]

Myelin bodies were isolated from the renal cortex of gentamicin-treated rats (100 mg/kg body weight, twice daily for 3 days, i.p.) employing an initial pelleting by differential centrifugation and subsequent flotation on a discontinuous sucrose gradient. These structures were found to contain almost twice as much protein as phospholipid and SDS-polyacrylamide gel electrophoresis revealed the presence of many different polypeptides. All the major phospholipids are present, although myelin bodies contain a considerably higher proportion of phosphatidylinositol, somewhat more phosphatidylcholine and considerably lower percentages of phosphatidylserine and sphingomyelin than do normal renal phospholipids. The fatty acids of myelin body phospholipids are highly saturated (67.3-87.9%) and a striking feature is the occurrence of relatively large amounts of 22:1, presumably erucic acid, especially in sphingomyelin. Myelin bodies contain small amounts of unesterified cholesterol, unesterified dolichol and coenzymes Q9 and Q10.

Place, publisher, year, edition, pages
Elsevier, 1991. Vol. 181, no 2, 894-901 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-99876ISI: A1991GV23700059PubMedID: 1661593OAI: oai:DiVA.org:liu-99876DiVA: diva2:658718
Available from: 2013-10-22 Created: 2013-10-22 Last updated: 2017-12-06Bibliographically approved

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Söderström, Mats

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