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Epithelial cells in nasal fluids from patients with allergic rhinitis: how do they relate to epidermal growth factor, eosinophils and eosinophil cationic protein?
Malmö University Hospital, Sweden.
Malmö University Hospital, Sweden.
Malmö University Hospital, Sweden.
2002 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 122, no 2, 202-205 p.Article in journal (Refereed) Published
Abstract [en]

The nasal epithelium protects the underlying tissue from damage. Epithelial cell growth is controlled by epidermal growth factor (EGF) and is possibly affected by toxic proteins, e.g. eosinophil cationic protein (ECP). The aims of this study were to examine nasal fluid epithelial cell counts and their relations to EGF, eosinophils and ECP in 23 patients with seasonal allergic rhinitis and 20 healthy controls. Nasal fluid epithelial cell counts were lower in patients than in controls. EGF levels did not differ between patients and controls, and correlated with epithelial cell counts in controls but not in patients. Eosinophils and ECP were higher in patients than in controls, but did not correlate with epithelial cell counts. The role of growth factors, such as EGF, in regulating epithelial cells merits further study.

Place, publisher, year, edition, pages
Taylor & Francis, 2002. Vol. 122, no 2, 202-205 p.
Keyword [en]
allergic rhinitis, eosinophil, cationic protein, eosinophils, epidermal growth factor, nasal fluid epithelial cells
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-99902PubMedID: 11936914OAI: diva2:658866
Available from: 2013-10-23 Created: 2013-10-23 Last updated: 2013-11-01Bibliographically approved

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Benson, Mikael
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