Cytokines in nasal fluids from school children with seasonal allergic rhinitis
1997 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 8, no 3, 143-149 p.Article in journal (Refereed) Published
Allergic rhinitis is a particularly good model for studies of cytokine production in vivo. In this study the occurrence of the cytokines IL-4, IL-5, IL-10 and IFN-gamma as well as the soluble receptor for IL-4 in nasal lavage fluids were assayed in 38 school children, with seasonal allergic rhinitis, and 19 healthy age-matched, non-atopic controls, using highly sensitive enzyme immunoassays. IL-4 levels in patients with seasonal allergic rhinitis were markedly increased in comparison with those in non-atopic controls or in atopic patients before the start of the pollen season. In controls, but not in the atopic patients, levels of IFN-gamma and IL-5 were significantly higher in specimens obtained during the pollen season than in those obtained outside the season. The IL-4/IFN-gamma ratios were significantly higher in atopic than in non-atopic subjects and further increased in atopic patients during the season. In addition to IL-4, elevated levels of IL-10 were observed in association with seasonal rhinitis. Following treatment with a topical steroid (budesonide) there was a statistically significant increase of the levels of soluble IL-4 receptor. These findings indicate that nonatopic and atopic individuals react to pollen exposure with distinct cytokine patterns in agreement with the Th1/Th2 concept. Topical steroids may possibly decrease inflammation by increasing the formation of soluble IL-4 receptor.
Place, publisher, year, edition, pages
Wiley-Blackwell, 1997. Vol. 8, no 3, 143-149 p.
cytokines, seasonal allergic rhinitis; school children, nasal fluid; budesonide
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-99925DOI: 10.1111/j.1399-3038.1997.tb00168.xPubMedID: 9532255OAI: oai:DiVA.org:liu-99925DiVA: diva2:658900