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Cytokines in nasal fluids from school children with seasonal allergic rhinitis
Sahlgrenska University Hospital, Göteborg, Sweden.
Sahlgrenska University Hospital, Göteborg, Sweden.
Sahlgrenska University Hospital, Göteborg, Sweden.
Sahlgrenska University Hospital, Göteborg, Sweden.
1997 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 8, no 3, 143-149 p.Article in journal (Refereed) Published
Abstract [en]

Allergic rhinitis is a particularly good model for studies of cytokine production in vivo. In this study the occurrence of the cytokines IL-4, IL-5, IL-10 and IFN-gamma as well as the soluble receptor for IL-4 in nasal lavage fluids were assayed in 38 school children, with seasonal allergic rhinitis, and 19 healthy age-matched, non-atopic controls, using highly sensitive enzyme immunoassays. IL-4 levels in patients with seasonal allergic rhinitis were markedly increased in comparison with those in non-atopic controls or in atopic patients before the start of the pollen season. In controls, but not in the atopic patients, levels of IFN-gamma and IL-5 were significantly higher in specimens obtained during the pollen season than in those obtained outside the season. The IL-4/IFN-gamma ratios were significantly higher in atopic than in non-atopic subjects and further increased in atopic patients during the season. In addition to IL-4, elevated levels of IL-10 were observed in association with seasonal rhinitis. Following treatment with a topical steroid (budesonide) there was a statistically significant increase of the levels of soluble IL-4 receptor. These findings indicate that nonatopic and atopic individuals react to pollen exposure with distinct cytokine patterns in agreement with the Th1/Th2 concept. Topical steroids may possibly decrease inflammation by increasing the formation of soluble IL-4 receptor.

Place, publisher, year, edition, pages
Wiley-Blackwell, 1997. Vol. 8, no 3, 143-149 p.
Keyword [en]
cytokines, seasonal allergic rhinitis; school children, nasal fluid; budesonide
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-99925DOI: 10.1111/j.1399-3038.1997.tb00168.xPubMedID: 9532255OAI: diva2:658900
Available from: 2013-10-23 Created: 2013-10-23 Last updated: 2013-11-01Bibliographically approved

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