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Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria
East Hospital, Göteborg, Sweden.
Göteborg University, Sweden.
Lund University, Sweden.
Sahlgrenska University Hospital, Göteborg, Sweden.
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1996 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 174, no 5, 1080-1084 p.Article in journal (Refereed) Published
Abstract [en]

Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responses were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.

Place, publisher, year, edition, pages
Oxford University Press, 1996. Vol. 174, no 5, 1080-1084 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-99926DOI: 10.1093/infdis/174.5.1080PubMedID: 8896512OAI: diva2:658905
Available from: 2013-10-23 Created: 2013-10-23 Last updated: 2013-11-01

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Benson, Mikael
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