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A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Division of Microbiology and Molecular Medicine. Linköping University, Faculty of Health Sciences.
2014 (English)In: Journal of Theoretical Biology, ISSN 0022-5193, E-ISSN 1095-8541, Vol. 342, 23-32 p.Article in journal (Refereed) Published
Abstract [en]

There is a large body of literature describing molecular level interactions between Mycobacterium tuberculosis (Mtb) and macrophages. Macrophages initiate a range of anti-bacterial mechanisms in response to infection, and Mtb is capable of surviving and circumventing many of these responses. We apply a computational approach to ask: what are the effects on the cellular level of these opposing interactions? The model considers the interplay between bacterial killing and the pathogen's interference with macrophage function. The results reveal an oscillating balance between host and pathogen, but the balance is transient and varies in length, indicating that stochasticity in the bacterial population or host response could contribute to the diverse incubation periods observed in exposed individuals. The model captures host and strain variation and gives new insight into host-pathogen compatibility and co-evolution.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 342, 23-32 p.
Keyword [en]
Variable diseaseoutcomes, Macrophage function, Individual-based model
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-99946DOI: 10.1016/j.jtbi.2013.09.029ISI: 000330257900003PubMedID: 24112967OAI: oai:DiVA.org:liu-99946DiVA: diva2:658968
Available from: 2013-10-23 Created: 2013-10-23 Last updated: 2017-12-06

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Pienaar, ElsjeLerm, Maria

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  • Other style
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  • de-DE
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  • nn-NB
  • sv-SE
  • Other locale
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