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Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve
Yale University School of Medicine, New Haven, CT, USA.
Dartmouth Medical School, Lebanon, NH, USA.
Dartmouth Medical School, Lebanon, NH, USA.
Dartmouth Medical School, Lebanon, NH, USA.
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2005 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 102, no 31, 10999-11004 p.Article in journal (Refereed) Published
Abstract [en]

The genetic loss of endothelial-derived nitric oxide synthase (eNOS) in mice impairs vascular endothelial growth factor (VEGF) and ischemia-initiated blood flow recovery resulting in critical limb ischemia. This result may occur through impaired arteriogenesis, angiogenesis, or mobilization of stem and progenitor cells. Here, we show that after ischemic challenge, eNOS knockout mice [eNOS (-/-)] have defects in arteriogenesis and functional blood flow reserve after muscle stimulation and pericyte recruitment, but no impairment in endothelial progenitor cell recruitment. More importantly, the defects in blood flow recovery, clinical manifestations of ischemia, ischemic reserve capacity, and pericyte recruitment into the growing neovasculature can be rescued by local intramuscular delivery of an adenovirus encoding a constitutively active allele of eNOS, eNOS S1179D, but not a control virus. Collectively, our data suggest that endogenous eNOS-derived NO exerts direct effects in preserving blood flow, thereby promoting arteriogenesis, angiogenesis, and mural cell recruitment to immature angiogenic sprouts.

Place, publisher, year, edition, pages
2005. Vol. 102, no 31, 10999-11004 p.
Keyword [en]
angiogenesis, arteriogenesis, genetics
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-99989DOI: 10.1073/pnas.0501444102PubMedID: 16043715OAI: oai:DiVA.org:liu-99989DiVA: diva2:659193
Available from: 2013-10-24 Created: 2013-10-24 Last updated: 2017-12-06Bibliographically approved

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de Muinck, Ebo D.

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
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Output format
  • html
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