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Intra-operative colloid administration increases the clearance of a post-operative fluid load
Hvidovre University Hospital, Denmark.
Clinical Research Centre, Södertälje, Sweden.
Hvidovre University Hospital, Denmark.
Hvidovre University Hospital, Denmark.
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2009 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 53, no 3, 311-317 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: It is unknown whether an intra-operative colloid infusion alters the dynamics of a crystalloid load administered post-operatively.

METHODS: Ten patients received 12.5 ml/kg of Ringer's lactate over 30 min 1-3 days before and 4 h after laparoscopic cholecystectomy, during which 10 ml/kg of a colloid solution, hydroxyethylstarch (HES 130/0.4), was infused. The total body clearance of the pre- and post-operative test infusions was taken as the ratio between the urinary excretion and the Hb-derived dilution of venous plasma over 150 min. The plasma clearance of the infused fluid was calculated using volume kinetics based on the plasma dilution alone. The pre-operative plasma clearance was compared with the post-operative plasma clearance and patients served as their own control.

RESULTS: The urinary excretion averaged 350 ml for the pre-operative infusion and 612 ml post-operatively, which corresponds to 46% and 68% of the pre- and post-operative infusions, respectively. The total body clearance of the crystalloid fluid was 30 ml/min before surgery and 124 ml/min after surgery (P<0.01). The plasma clearance, as obtained from the plasma dilution alone, was 28 and 412 ml/min, respectively. The maximal increase in plasma volume was 410 ml pre-operatively vs. 220 ml post-operatively.

CONCLUSIONS: Infusion of a colloid solution in combination with a crystalloid during laparoscopic cholecystectomy increased the plasma clearance of a post-operative crystalloid infusion.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2009. Vol. 53, no 3, 311-317 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100201DOI: 10.1111/j.1399-6576.2008.01857.xPubMedID: 19243316OAI: diva2:660721
Available from: 2013-10-30 Created: 2013-10-30 Last updated: 2013-11-12Bibliographically approved

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Hahn, Robert G.
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