Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)
2003 (English)In: Journal of Experimental and Clinical Cancer Research, ISSN 0392-9078, E-ISSN 1756-9966, Vol. 22, no 3, 471-475 p.Article in journal (Refereed) Published
Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.
Place, publisher, year, edition, pages
BioMed Central, 2003. Vol. 22, no 3, 471-475 p.
Id2; all-trans retinoic acid; THP-1 cells; differentiation; proliferation; helix-loop-helix
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-100366ISI: 000185882000018OAI: oai:DiVA.org:liu-100366DiVA: diva2:661592