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The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents
Karolinska Institutet, Stockholm, Sweden.
University of Örebro, Sweden.
University of Örebro, Sweden.
Karolinska Institutet, Stockholm, Sweden.
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2005 (English)In: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 25, no 7, E113-E116 p.Article in journal (Refereed) Published
Abstract [en]

Objective-Inflammatory processes play an important role in atherosclerosis, and increasing evidence implies that microbial pathogens and proinflammatory cytokines are involved in the development and activation of atherosclerotic lesions. To find new inflammatory genes, we explored the vascular transcriptional response to an activator of innate immunity bacterial lipopolysaccharides (LPSs). Methods and Results-Gene arrays identified the cytomegalovirus-inducible gene 5 (cig5)/viperin among the genes most potently induced by LPS in human vascular biopsies. Viperin was expressed by endothelial cells in atherosclerotic arteries and significantly elevated in atherosclerotic compared with normal arteries. In culture, cytomegalovirus infection, interferon-gamma, and LPS induced viperin expression. Conclusion-Viperin is expressed in atherosclerosis and induced in vascular cells by inflammatory stimuli and cytomegalovirus infection. The putative functions of viperin in atherosclerosis may relate to disease-associated microbes.

Place, publisher, year, edition, pages
American Heart Association , 2005. Vol. 25, no 7, E113-E116 p.
Keyword [en]
atherosclerosis; gene expression; cytomegalovirus; inflammation; viperin
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-100359DOI: 10.1161/01.ATV.0000170130.85334.38ISI: 000230112200039OAI: oai:DiVA.org:liu-100359DiVA: diva2:661604
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2017-12-06Bibliographically approved

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Wågsäter, Dick

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