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Expression of interleukin-17 in human colorectal cancer
Karolinska Institute, Stockholm, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
Ryhov County Hospital, Jönköping, Sweden.
University College of Health Sciences, Jönköping, Sweden.
2006 (English)In: Anticancer Research, ISSN 0250-7005, Vol. 26, no 6B, 4213-4216 p.Article in journal (Refereed) Published
Abstract [en]

The proinflammatory cytokine IL-17 plays a potential role in T-cell mediated angiogenesis and promotes tumourigenicity of human cervical cancer. The objective of this study was to determine whether IL-17 protein level is altered in colorectal tumours (n=74) compared with paired normal mucosa and in plasma from patients (n=61) with colorectal cancer (CRC) compared with a healthy group (n=78). Analyses by ELISA showed that IL-17 protein was undetectable in 48.6% of the patients with cancer, as well as corresponding normal tissue which may in part reflect an individual difference. No significant difference was observed regarding IL-17 protein levels between cancer and matched normal tissue or in plasma between patients and the healthy group. Immunohistochemistry (n=20) revealed heterogenous immunoreactivity in 65% of the cases. The results of this study suggest that IL-17 plays a minor or partial role in CRC.

Place, publisher, year, edition, pages
International Institute of Anticancer Research (IIAR) , 2006. Vol. 26, no 6B, 4213-4216 p.
Keyword [en]
interleukin-17; protein expression; colorectal cancer
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100353ISI: 000243040300017PubMedID: 17201135OAI: diva2:661612
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2013-11-15Bibliographically approved

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Wågsäter, Dick
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