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Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter −420C > G genotype
Karolinska Institute, Stockholm, Sweden.
Al-Nahrain University, Baghdad, Iraq.
Ryhov County Hospital, Jönköping, Sweden .
University College of Health Sciences, Jönköping, Sweden.
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2008 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, no 10, 1008-1014 p.Article in journal (Refereed) Published
Abstract [en]

A single nucleotide polymorphism (SNP) -420Cgreater than G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420Cgreater than G resistin polymorphism is not a potential genetic susceptibility factor.

Place, publisher, year, edition, pages
Informa Healthcare, 2008. Vol. 26, no 10, 1008-1014 p.
Keyword [en]
Resistin; Protein expression; Colorectal cancer; Polymorphism
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-100347DOI: 10.1080/07357900802087267ISI: 000261802800008OAI: diva2:661620
Available from: 2013-11-04 Created: 2013-11-04 Last updated: 2013-11-15Bibliographically approved

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Wågsäter, Dick
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