Resistin in Human Colorectal Cancer: Increased Expression Independently of Resistin Promoter −420C > G genotype
2008 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 26, no 10, 1008-1014 p.Article in journal (Refereed) Published
A single nucleotide polymorphism (SNP) -420Cgreater than G of the resistin gene was screened in 248 colorectal cancer (CRC) patients and 256 controls. No significant difference in genotype distribution was found. However, we found an upregulation in 92% of the samples in the levels of resistin protein in cancer tissue (n = 83). Immunohistochemical analysis revealed heterogenous staining of resistin predominantly in the cancer tissue. Further, resistin induced secretion of MMP-2 and MMP-9 from monocytes. The results of this study suggest that resistin may play a partial role in CRC but that the -420Cgreater than G resistin polymorphism is not a potential genetic susceptibility factor.
Place, publisher, year, edition, pages
Informa Healthcare, 2008. Vol. 26, no 10, 1008-1014 p.
Resistin; Protein expression; Colorectal cancer; Polymorphism
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-100347DOI: 10.1080/07357900802087267ISI: 000261802800008OAI: oai:DiVA.org:liu-100347DiVA: diva2:661620